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Interestingly, although increased PHGDH expression supports cancer cell proliferation, studies have demonstrated that low PHGDH induces abnormal protein glycosylation through activation of the hexosamine-sialic acid pathway, thus non-catalytically enhancing cancer spread and metastasis (Rossi et al., 2022)

Akinola A, Oyeyemi A, Daramola O, Raji Y (2020) Effects of the methanol root extract of Carpolobia lutea on sperm indices, acrosome reaction, and sperm DNA integrity in cadmium-induced reproductive toxicity in male Wistar rats

379 Additionally, PTP4A2 regulates GBM recurrence via roundabout guidance receptor 1 (ROBO1), and CAR-T cell targeting of ROBO1 improves survival in recurrent GBM models, highlighting a potential therapeutic strategy for GBM

Dave Brubeck (1920-2012) Date: March 21, 2013 Event: Music Department Noonday Concert Location: Dickinson College Isabel I Burlingame Souvenir d'un lieu cher, Op